William Donohue is one of the leaders of the Catholic League and a happy partner with none other than Snappy O'Berine, (They are made for each other) but really he's known for his outrageously idiotic tirades against Hollywood and liberals on the talking head shows.
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Stewart catches him at his best.

Donohue: They will do anything for a buck, they wouldn't care. If you asked them to sodomize their own mother in a movie they would do so-and they would do it with a smile on their face.

Stewart: In my defense I was young, and I needed the money.

Donohue then takes on O'Reilly's persona and tells the other guest to " Shut Up." With him as a representative, no wonder Catholicism gets a bad name at times.