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MSNBC has the scoop. David Petraeus has submitted a letter of resignation from the CIA, which has been accepted by President Obama. Apparently, Petraeus has cited an extra-marital affair as one of the contributing factors.
More information as it develops...
Update: No video yet, but the text of his resignation letter is on MSNBC's site.
Update #2: Just added the video from Andrea Mitchell's show with the original breaking news report.